Third Party Analytical Integration

Implementation of Process Analytical Technology (PAT) in your bioreactor system requires that at-line samples that are automatically collected, be automatically analyzed. We have a long history of successfully resolving integration and development challenges. Let us help you interface the MAST system with your most difficult PAT process. Together we can create a real product quality attribute controlled process.

Below are some of the Analytical Instruments and Liquid Handling Solutions we have integrated with:

Gilson Liquid Handling Equipment

MAST integration software communicates with the Gilson Trilution software utilizing the full capabilities of the Gilson liquid handling system

Can receive whole broth samples directly from a Sample Pilot, or cell-free samples from the MAST cell removal system

Can save samples as a chilled retain, or process the samples with all of the methods available to the Gilson system, including Protein A, solid phase extraction, digestions, pre-filtrations, de-aminations, and dilutions. Methods are run automatically as ordered in the MAST scheduling software

Processed samples can be delivered to downstream devices, such as the Waters PATROL UPLC for automated analysis

Nova Medical BioProfile FLEX

Nova Medical BioProfile FLEX2

Roche CEDEX BioHT

Waters Acquity Systems including the Waters PATROL using Empower 3

MAST integration software communicates with the Gilson Trilution software and the Empower 3 Toolkit software to initiate sample collection and processing

Methods available in the Waters PATROL system can be accessed by the MAST system during sample scheduling

Cell-free samples processed by the Gilson can be transferred to the Waters PATROL system for automated analysis using the method selected in the MAST system

Thermo Fisher LC Integration via Chromeleon

Agilent LC Integration via ChemStation

Cary 60 UV/Vis Analyzer

Ongoing Development Programs

The MAST team has an ongoing program of integrating third-party analytical devices. Development programs underway include integration with the CEDEX HiRes and the ViCell. We are also working on multiple development projects associated with integrating with data historians like PI or supervisory data-management & control systems like Delta V or other client-specific data-management systems. If your analyzer or data management system is not described here, we can put together a straightforward integration development program to get you connected.